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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NCL All Species: 35.45
Human Site: S619 Identified Species: 78
UniProt: P19338 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P19338 NP_005372.2 710 76614 S619 F G F V D F N S E E D A K A A
Chimpanzee Pan troglodytes XP_516145 1006 108719 S915 F G F V D F N S E E D A K A A
Rhesus Macaque Macaca mulatta XP_001116949 938 100743 S847 F G F V D F N S E E D A K A A
Dog Lupus familis XP_850477 699 75739 S608 F G F V D F N S E E D A K A A
Cat Felis silvestris
Mouse Mus musculus P09405 707 76705 S616 F G F V D F N S E E D A K A A
Rat Rattus norvegicus P13383 713 77129 S622 F G F V D F N S E E D A K A A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509329 631 67414 T564 F G F V D F N T A E E A K A A
Chicken Gallus gallus P15771 694 75622 S600 F G F V D F S S P E D A K A A
Frog Xenopus laevis P20397 651 70177 T550 F G F V D F S T A E D A K A A
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797746 400 43419 K368 D E R T L F A K G L S Y S T S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P27476 414 44517 R382 R G G A R G G R G G F R P S G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 70.3 74.7 91.6 N.A. 83.9 84.2 N.A. 65.6 63.2 55.6 N.A. N.A. N.A. N.A. N.A. 24
Protein Similarity: 100 70.4 75.4 94.9 N.A. 90.1 90.4 N.A. 73.9 76 68.4 N.A. N.A. N.A. N.A. N.A. 32.8
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 80 86.6 80 N.A. N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 93.3 93.3 93.3 N.A. N.A. N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 23.1 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 35.4 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 10 0 0 10 0 19 0 0 82 0 82 82 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 0 0 82 0 0 0 0 0 73 0 0 0 0 % D
% Glu: 0 10 0 0 0 0 0 0 55 82 10 0 0 0 0 % E
% Phe: 82 0 82 0 0 91 0 0 0 0 10 0 0 0 0 % F
% Gly: 0 91 10 0 0 10 10 0 19 10 0 0 0 0 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 10 0 0 0 0 82 0 0 % K
% Leu: 0 0 0 0 10 0 0 0 0 10 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 64 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 10 0 0 0 10 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 10 0 10 0 10 0 0 10 0 0 0 10 0 0 0 % R
% Ser: 0 0 0 0 0 0 19 64 0 0 10 0 10 10 10 % S
% Thr: 0 0 0 10 0 0 0 19 0 0 0 0 0 10 0 % T
% Val: 0 0 0 82 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _